Global supply chains have faced disruption in recent years—and uncertainty is likely to persist. The United Nations’ 2025 “Trade and development foresights” report notes that policy unpredictability is at historic highs, affecting business decisions and investment planning globally.1 Ongoing geopolitical events and evolving trade policies across major economies are increasing supply chain complexity, raising input costs, and disrupting investment and logistics.2
In this environment, manufacturers should have new tools to help manage risk and remain competitive. Agentic AI—that is, artificial intelligence systems that can reason, plan, and act with autonomy3—can offer companies transformative solutions for building more resilient, responsive supply chains and unlocking new sources of value. Adoption is already accelerating: A recent study indicates that more than half of surveyed supply chain executives report deploying AI agents to automate workflows.4 According to Gartner®, “by 2030, 50% of cross-functional supply chain management solutions will use intelligent agents to autonomously execute decisions in the ecosystem.”5 The company also states that “40% of enterprise applications will be integrated with task-specific AI agents by the end of 2026, up from less than 5% today.”6
Many supply chain processes today have been designed around human constraints, with sequential decision-making, manual handoffs, and limited visibility. Agentic AI has the potential to revolutionize the status quo. AI agents possess short- and long-term memory, access a wide variety of tools, and can reason, plan, and act autonomously to achieve specific objectives.7 Unbound by human bandwidth, they can continuously coordinate decisions and actions across suppliers, plants, logistics partners, and planning functions, creating value in three ways:
To maximize this value, however, companies should reimagine and redesign supply chain workflows around the unique strengths of humans and agents rather than simply inserting AI agents into existing operating models.8
To accomplish this goal, business and technology leaders, solution providers, and process experts, including process owners and stakeholders, should partner to identify where agents can be leveraged across supply chain operations.9 Software tools can help teams identify repetitive, rules-based, or coordination-intensive activities that are strong candidates for automation. The redesign effort can then focus on developing coordinated, cross-functional, and cross-system workflows that enable governed, real-time sensing, decision-making, and execution.
When reimagining supply chains for agentic AI, it can be helpful to think of agents as having “resumes,” just as human workers do, with unique knowledge, skills, and abilities to use various tools. Unlike deterministic robotic process automation, which follows predefined rules, agents reason probabilistically across complex conditions and adapt dynamically, making context-aware decisions and taking action within defined guardrails rather than simply executing scripts.
For example, an Inventory Agent—powered by large language models for contextual knowledge, specialized reasoning models, and domain-specific algorithms for quantitative insights—could bring deep knowledge of inventory positions, service levels, holding costs, lead-time variability, and stockout risk across the supply network. Its core skills might include optimizing safety stock, recalculating service levels, and balancing working capital against production continuity. The agent could have governed access to enterprise resource planning systems and inventory optimization tools, enabling it to continuously adjust inventory policies within specified thresholds. It could also offer novel capabilities, such as generating targeted scripts or workflow automations that leverage application programming interfaces to address emerging inventory scenarios, reducing the cost and delay of manual software customization. High-impact trade-offs or actions outside defined guardrails would be escalated to humans when strategic judgment is required.
In a reimagined agentic supply chain (figure 1), domain agents serve as orchestration layers and outcome owners, enforcing policies and guardrails to accomplish defined objectives. They coordinate task-specific agents and tools—including robotic process automation bots and other intelligent automation—that retrieve and structure data, perform bounded analysis, and execute governed actions across existing systems of record and external platforms. Cross-functional agents provide enterprisewide risk intelligence and shared governance across planning, finance, and operations to help ensure decisions remain aligned and compliant, and maximize business value.
While agents focus on “always-on” sensing, analysis, and governed action (figure 2), human roles shift from routine execution toward oversight, orchestration, and ethical and strategic judgment.10 Humans and agents interact across multiple modes—including embedded copilots, conversational chat, messaging and email tools, and automated voice interactions—moving beyond static dashboards to more dynamic, real-time collaboration.
From disruptive approaches to supply chain planning and inventory management to formulating agile, data-driven sourcing strategies amid ongoing supply chain uncertainty and complexity, the use cases below highlight the potential of agentic supply chains.
Disruption monitoring in supply chains is often episodic, siloed, and reactive, relying on periodic reviews, manual alerts, fragmented visibility, and uncoordinated responses across systems. Led by the Supply Risk and Resilience Agent, an agentic supply chain can continuously monitor external events, such as weather, labor actions, and geopolitical shocks, alongside internal execution signals and real-time supplier performance data, through specialized monitoring and analytics agents. By linking these signals to production schedules and material requirements, the agent can proactively assess the impact of potential disruptions based on timing and operational criticality. It can autonomously execute preapproved mitigation actions, such as resequencing production or communicating with suppliers through messaging or voice channels, while escalating only novel or high-risk scenarios to humans before disruptions cascade into downtime or missed customer commitments. The potential impact: a step-change improvement in predictability, agility, and resilience.
Logistics execution is often dominated by manual coordination of unconnected activities—soliciting carrier bids, confirming availability, reconciling rates, and reacting to delays. Led by the Logistics Agent, which orchestrates booking, communication, and other specialized task agents, an agentic supply chain can detect shipment demand and capacity gaps in real time, solicit and compare carrier bids, validate contractual and policy compliance, and autonomously book carriers and update logistics systems within defined guardrails. It can also confirm availability via messaging apps, email, or automated voice when required. When disruptions, such as weather events, port congestion, or traffic delays occur, agents can automatically rebook, reroute, or reprioritize shipments, escalating premium freight decisions or dispute resolution to humans. The potential impact: consistent capacity coverage, reduced freight variability, and improved logistics efficiency and agility.
Customs filings often rely on high-level invoice descriptions and manual broker interpretation, increasing the risk of misclassification, delays, and potentially unnecessary tariff exposure. In short, value can be lost by not understanding exactly what’s in a shipping container. In an agentic supply chain, the Production Agent can analyze bill of materials (BOM) structures to determine the actual material composition of goods in each shipment. The Data and Governance Agent can then apply the appropriate trade classifications, rules, and eligible mitigations based on that composition, and generate and submit compliant filings subject to defined human approval thresholds. By systematically linking product structure to regulatory logic, agents can reduce avoidable costs, improve auditability, and accelerate clearance, strengthening compliance while lowering total landed cost.
Many organizations still rely on static service-level policies that are reviewed periodically and applied to a limited set of critical parts. An Inventory Agent can continuously optimize service levels and safety stock at the part level based on demand variability and supply reliability. It can achieve this by leveraging simulation, forecasting, and other specialized task agents to optimize holding cost and stockout risk trade-offs. This continuous, data-driven approach, which could be applied across thousands of parts rather than a select few, frees working capital while reducing downtime risk and improving cost performance, resilience, and predictability.
Procurement involves manual activities, such as status checks, follow-ups, and invoice reconciliation, which consume substantial human time and effort. A Procurement Agent can autonomously execute routine procure-to-pay activities end-to-end through transaction, reconciliation, and communication agents, while also supporting upstream sourcing decisions, monitoring purchase orders, and resolving common exceptions. This can reduce coordination friction and cycle times while allowing procurement teams to improve efficiency and long-term performance by focusing on higher-value activities, such as supplier strategy, complex negotiations, and high-level decision-making.
Periodic supplier risk reviews, manual sourcing evaluations, and reactive responses to policy changes and geopolitical events remain common in current supply chains. In an agent-enabled model, agents continuously sense structural supplier risk, external disruptions, and evolving trade and regulatory constraints. By integrating multitier supplier risk, capacity, and sourcing dependencies with real-time policy intelligence, agents can proactively generate and rank executable sourcing and supply network restructuring options, such as dual sourcing, nearshoring, supplier transitions, or vertical integration. Once approved, they initiate supplier onboarding workflows, update sourcing allocations in enterprise systems, and monitor transition progress against defined guardrails. Humans steward key relationships, apply strategic judgment, lead negotiations, and approve high-impact or ambiguous trade-offs. The result can be faster, more informed supply network decision-making that strengthens resilience, compliance, and long-term cost performance. The detailed tasks agents and humans perform to make it all happen are shown below.
Agent tasks
Human tasks
In addition to taking a holistic approach to preparing for a future with agentic AI, organizations should pay particular attention to a few critical elements to enable sustained value realization when agentifying their supply chains (figure 3).
Together, these elements can help position organizations to move beyond isolated automation toward truly agentic supply chains capable of continuous sensing, coordinated decision-making, and governed execution at scale. The companies that redesign workflows and operating models around the complementary strengths of agents and humans—rather than layering agents onto existing processes—may be best positioned to navigate complex supply chain challenges, build resilience, and create sustained competitive advantage.